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Whats the next NEW Opiate Drug out now?


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#1 codynunn6

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Posted May 06 2012 - 03:25 PM

Im just wondering. I know OXY was the biggest back in the day.. sadly enought i got in the game right when oxy had left the market... Then they brought out the Shitty OPs... Then The Opanas which sadly i fell in love with.. Now the Opanas are gone : ( but i know they have reformulated the Opanas like the OP .. But i was just wondering if they were going to make something else also? can anyone help me out? i heard somthing about Hydro 100s.. is that true or total Bull shit... I know it will NEVER compare to a Opana 40 tho... Just tell me what you guys think or know! thanks!!! :)

#2 Fieldofpoppies

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Posted May 06 2012 - 03:50 PM

No clue about the hydro 100s, but i have heard that some company somewhere may be developing pills of pure hydro without acetaminophen in them. Not sure if its gonna be "the next big thing" or not, or even if it's 100% true.

#3 hydropersistant

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Posted May 06 2012 - 04:08 PM

That rumor is 100% true and it's in the final phases of testing. It's called zohydro. It is supposed to be a "pure" or single entity opiate used for moderate to severe pain. I think the doses are like 25&50mg pills which would still be crazy but it's supposed to be a capsul and I'm sure it will have those little beads in them that are damn near impossible to break so I'm not sure how "abusable" they will be. I'm looking forward to them as I'm a CPP and ER hydrocodone sounds good to me!

#4 etkearne

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Posted May 07 2012 - 12:35 PM

The next big thing will be Zohydro obviously (unless for some reason it doesn't make it to market). Then, people should keep their eyes out for the introduction of Hydromorphone ER in the USA. It is marketed as Palladone and Jurista in other countries but we don't have it yet in the USA. THAT has the potential to be a hugely popular product that could top Opana's fame easily.
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#5 hydropersistant

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Posted May 07 2012 - 12:54 PM

Mmmm palladone. I would shit a brick if I got a hold of one of those!! It would prolly be bad. I'd have to REALLY be careful as I like dillys a lot. Man now I'm gunna be stuck on wiki and google for the next 6 hours dreaming of drugs I can't have! NOOOOOOO!!

#6 p0rkch0p

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Posted May 07 2012 - 05:23 PM

The next big thing will be Zohydro obviously (unless for some reason it doesn't make it to market). Then, people should keep their eyes out for the introduction of Hydromorphone ER in the USA. It is marketed as Palladone and Jurista in other countries but we don't have it yet in the USA. THAT has the potential to be a hugely popular product that could top Opana's fame easily.


not true, we do have it here call exalgo, was onit a while ago before i got switched to the oana, check this link, i made a entry on the subject
http://www.topix.com...8ML8T48BFQVH0NF
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#7 etkearne

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Posted May 08 2012 - 11:52 AM

not true, we do have it here call exalgo, was onit a while ago before i got switched to the oana, check this link, i made a entry on the subject
http://www.topix.com...8ML8T48BFQVH0NF


Interesting. I never heard of it. Do you know if it is relatively "popular" in the PM community? It seems like PM docs mainly script MS Contin, OxyContin, Fentanyl (transdermal), or Opana ER for all-day pain relief, while scripting a wide variety of stuff for breakthrough.

Did you find it to be a good analgesic? Or was the oral bio-availability so low that it was frustrating? How was it mentally? More like a Morphine high (dreamy and mildly euphoric) or a Oxycodone high (alert and sharply euphoric)?

Thanks for the information.
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#8 Pillowpantslol

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Posted May 08 2012 - 12:33 PM

I've taken large doses of Hydro before made from cold water extraction. Mg to mg it's about as strong as Oxy, maybe just a tad weaker. It's more dreamy like morphine and about as euphoric as oxy. That's just me. Personally I find morphine to be FAR more euphoric and dreamy than oxy, so my experience may not strictly apply.

#9 Pillowpantslol

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Posted May 08 2012 - 12:35 PM

I probably could not tell the difference between hydrocodone and oxycodone if I didn't already know.

#10 etkearne

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Posted May 08 2012 - 12:48 PM

I've taken large doses of Hydro before made from cold water extraction. Mg to mg it's about as strong as Oxy, maybe just a tad weaker. It's more dreamy like morphine and about as euphoric as oxy. That's just me. Personally I find morphine to be FAR more euphoric and dreamy than oxy, so my experience may not strictly apply.


True. It is really down to personal tastes. I have just noticed that in general many people find Morphine to be more dreamy and less "sharply" euphoric than most of the semi-synthetics like Oxycodone, Buprenorphine, or synthetics like Meperidine.

You are also correct about the mg-to-mg comparison for Hydrocodone vs. Oxycodone. Hydrocodone is slightly weaker. Most literature states that 10 mg of Oxycodone is equivalent to 15 mg of Hydrocodone. However, I have seen the conversion as high as 10 mg vs. 20 mg and as low as 10 mg vs. 10 mg.
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#11 Pillowpantslol

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Posted May 08 2012 - 12:56 PM

Also: Morphine causes A LOT more respiratory depression than semi-synthetics like oxy or hydro, which could easily cause problems.

#12 etkearne

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Posted May 08 2012 - 01:50 PM

Also: Morphine causes A LOT more respiratory depression than semi-synthetics like oxy or hydro, which could easily cause problems.


Respiratory depression is regulated by the mu-opioid-2 receptor subtype. Morphine is a broad-spectrum opioid-receptor agonist. It is a strong agonist at the mu-opioid-1, mu-opioid-2, and a moderate agonist at the delta and kappa receptors as well (I am not sure about the sub-types of each receptor as I find the delta and kappa opioid receptors not as interesting).

However, most of the synthetics, except Meperidine, heavily favor agonist behavior at the mu-opioid-2 site, while being weaker at mu-opioid-1, and almost absent at the delta and kappa sites. It is worth noting that Meperidine is a strong kappa agonist, even more-so than its mu agonist affinity.

Looking at the mu-1 and mu-2 receptors, we notice that they induce separate effects. It has been found that mu-1 agonists (and partial agonists) induce strong analgesia and strong euphoria. That's the gist of mu-1. However, mu-2 agonists induce drowsiness, respiratory depression, and itchiness.

So, naturally, Morphine is more dangerous to use in high doses than an equipotent dose of, say, Fentanyl. While both compounds are mu-1 agonists, Morphine is also just as strong of a mu-2 agonist. So this is why Morphine is so prone to the effects you describe.

I can attest to this difference. I take Suboxone, which is Buprenorphine mixed with Naloxone (which doesn't contribute to the effects as it is sublingually inactive). Buprenorphine happens to be a very strong mu-1 receptor partial agonist (with intrinsic activity of around 70%), a strong delta agonist, and a moderately strong kappa antagonist. But it doesn't act very much as a mu-2 agonist. I rarely get tired on Suboxone. I have never gotten itchy on it, and never had respiratory depression. However, the analgesia and euphoria are strongly present.

However, I have taken Morphine before and I was shocked at the body load and "dreamy" character of it. IMO it detracted from the euphoria, but that is just personal preference, as, at the time, I was used to Tramadol and Oxycodone, which are not sedating in my experience.
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#13 Giggle Shards HD

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Posted May 08 2012 - 02:03 PM

boy do i ever get itchy on subs i can barley sit still without scratchin

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#14 etkearne

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Posted May 08 2012 - 02:29 PM

boy do i ever get itchy on subs i can barley sit still without scratchin


Really? Interesting, since Buprenorphine is mainly a mu-1-partial agonist, and, like I said, the mu-2 receptor is mainly responsible for itchiness.

I have never been the least bit itchy on Suboxone but with Hydrocodone and Morphine, I would itch the hell out of myself, especially my nose and legs.

What dose of Suboxone are you on, and how tolerant are you to opioids right now?
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#15 Pillowpantslol

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Posted May 09 2012 - 08:11 PM

I can't stand the itching, I never take opiates without Promethazine or Diphenhydramine.

#16 happydude_60

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Posted May 10 2012 - 01:24 AM

Yeah, but it feels so great when you scratch that itch, doesn't it? I have a flat tip screw driver for that purpose, to get at that pesky hard-to-reach area in the middle of my back. Oh, that's awesome! LOL

#17 hydropersistant

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Posted May 10 2012 - 11:27 AM

Mmmm morphine! I take 2 scoops please! Yea I seem to enjoy the "dirtier" opiates if that makes any sense. My favs being in no particular order morphine,hydrocodone(at the right dose), hydromorphone, I also enjoy oxy but i find it to be to alert feeling and I don't to much care for that. I prefer the low down heavy opiates with a big body load and good nod to it at the right dose, I like to "quiet my mind" and I find oxy isn't the best at that but it is better for getting stuff done.

#18 codynunn6

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Posted May 12 2012 - 01:04 PM

thanks for all the great response's guys! i appreciate it all. my first little thread went good. i learned a lot from all of your responses!

It has been super dry will all the opanas gone in my place right now. i have not had anything for 2 weeks. when im usually doing an opana every other day or so.. I ended up gettin scoring with 2 op 30s today. He/she is the only person i know that can get em, they only come in once a week now and he mainly just sells those to me which is great.. so my tolerance is more then likely down, so a little of it might get me trashed haha..

Everyone i know has switched over to the Subs. But i still dont know about em. i tried one a while back and i dont remember it doing much too me. But apparently everyone gets pretty trashed on em.

i see you all have been talking about the Hydromorphone or the 'Dilaudid' which i have had one time before . which i dont remeber the MG being very high. maybe a 4mg. which i have not seen on higher then a 8mg.. So are those still staying on the market?

again thanks for the response.

#19 Giggle Shards HD

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Posted May 13 2012 - 10:37 AM

Really? Interesting, since Buprenorphine is mainly a mu-1-partial agonist, and, like I said, the mu-2 receptor is mainly responsible for itchiness.

I have never been the least bit itchy on Suboxone but with Hydrocodone and Morphine, I would itch the hell out of myself, especially my nose and legs.

What dose of Suboxone are you on, and how tolerant are you to opioids right now?


i,m perscribed 8mgs a day suppoused to use 3/4 to a whole strip per day
but i try for 4mgs a day but most days its 6mgs only once i used a whole strip +2more mgs

i used to use alot of herion and or percs/vics and once in awhile fent. or them IR oxy,s but the first day on just 4mgs i got high as hell puked once sweating itchin, i could,nt beileve it. but now after 2 1/2 weeks here i dont itch as much and don,t get as high i got some chelted mag. you said for tol. can,t find the other ya ment. augmite? there,s only one specitally health store around here.

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#20 job1372

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Posted May 14 2012 - 02:23 AM

For me Hydros just make me wanna sleep. Oxys on the other hand are like morphine all fucked up on coke. And some one tell me i'm not alone and Oxy's don't make you puke. cuz everyone i know pukes a little while after snorting them and then it hits them. I've never felt the slightest bit pukey. but then again i am an oddball. for example ambiens make me wired not tired.

#21 codynunn6

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Posted May 14 2012 - 05:57 AM

For me Hydros just make me wanna sleep. Oxys on the other hand are like morphine all fucked up on coke. And some one tell me i'm not alone and Oxy's don't make you puke. cuz everyone i know pukes a little while after snorting them and then it hits them. I've never felt the slightest bit pukey. but then again i am an oddball. for example ambiens make me wired not tired.


your not alone man, i do not puke at all when i snort em... I heard of people maybe after snorting just get a little sick and then puke. Kinda like the first time someone ever blows an Opana and they do too much because they underestimate the strength of the pill.. Then they get sick and puke their guts out...

#22 p0rkch0p

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Posted May 22 2012 - 08:36 PM

BEDMINSTER, N.J. and SYDNEY, April 10, 2012 /PRNewswire/ -- QRxPharma (ASX: QRX and OTCQX: QRXPY) announced today successful completion of two Phase 1 studies in healthy volunteers for MoxDuo® CR, a controlled-release Dual-Opioid® utilising a 3:2 ratio of morphine and oxycodone. The proprietary MoxDuo CR formulation, encompassing both sustained delivery technology as well as abuse deterrent and tamper resistant features, is designed to provide at least 12 hours of analgesia in patients suffering from moderate to severe chronic pain including cancer, lower back, osteoarthritis and neuropathic pain. The clinical trials compared blood levels of MoxDuo CR's components to OxyContin® and MS Contin® and demonstrated MoxDuo CR's superior results, with sustained blood levels for up to 24 hours. Further studies indicated MoxDuo CR's increased resistance to tampering

Related Biotechnology, Pharmaceutical and Healthcare News
QRxPharma Successfully Completes Phase 1 Studies for MoxDuo® CR
QRxPharma Successfully Completes Phase 1 Studies for MoxDuo CR
QRxPharma concludes phase I studies for MoxDuo CR
QRxPharma completes Phase 1 Studies for MoxDuo
QRxPharma completes Phase I studies for MoxDuo CR
"The successful completion of these trials confirms the advantages of this formulation and enables QRxPharma to initiate Phase 2 Proof-of-Concept clinical studies mid-year 2012,"
said Dr. John Holaday, Managing Director and Chief Executive Officer of QRxPharma. "These data suggest MoxDuo CR may be positioned as a once or twice per day formulation for treating chronic pain, with the potential advantage of significantly reduced side effects as witnessed with immediate release MoxDuo. In the US alone, the chronic opioid pain market is a $6 billion a year opportunity."

Two Phase 1 trials were conducted in healthy volunteers to evaluate the rate at which key components of the MoxDuo controlled-release (CR) formulation were absorbed, distributed, metabolised and eliminated by the body. The first study compared MoxDuo CR (30mg morphine SO4/20mg oxycodone HCl) to the pharmacokinetic profiles of the same doses of MS Contin (30mg morphine SO4) and OxyContin (20 mg oxycodone HCl) in 10 healthy adult human subjects using a three-way crossover design. Pharmacokinetic results from the measurement of opioid blood levels over time revealed a MoxDuo CR profile consistent with expectations for a once to twice-daily formulation.

The second study demonstrated that food consumption does not alter the pharmacokinetic profiles of morphine and oxycodone from MoxDuo CR (30 mg/20 mg) tablets using a two-way crossover design with 17 healthy volunteers. To demonstrate the effects of chronic use on steady-state blood levels, this study also measured the repetitive-dose pharmacokinetic profiles of morphine and its metabolites as well as oxycodone during repetitive (twice daily) administration of MoxDuo CR tablets for 5 days.

The MoxDuo CR tablets used in these clinical tests included QRxPharma's proprietary Abuse Deterrence Formulation (ADF) technology. As an indication of tamper resistance, attempts to extract morphine or oxycodone by crushing and solubilising in water or alcohol resulted in very limited (less than 15%) drug recovery. In addition, the ADF technology did not impair human bioavailability of the opioids following oral administration.

"Clinical performance of the oral MoxDuo CR formulation clearly exceeded our expectations. When directly compared to OxyContin, the largest selling opioid for chronic pain, MoxDuo CR demonstrated superior bioavailabilty and sustained blood levels for over 12 hours, especially in the 12-24 hour time period. At steady-state, MoxDuo CR provided very low fluctuations of oxycodone. MoxDuo CR appears to be a true once or twice a day delivery system for dual opioids,"
said Dr. Ed Rudnic, Chief Operating Officer, QRxPharma.
"We expect that MoxDuo CR's sustained blood levels, ADF attributes and potential side effect benefits will enhance the tolerability and acceptability of MoxDuo CR in the global chronic pain marketplace."

The CR formulation of MoxDuo encompasses the same 3:2 ratio of morphine and oxycodone as in MoxDuo IR, QRxPharma's immediate release acute pain formulation that is scheduled for PDUFA feedback from the US Food and Drug Administration (FDA) in June 2012. QRxPharma's US partner for MoxDuo IR, Actavis, Inc has the option to negotiate for the US license of MoxDuo CR pending achievement of certain MoxDuo IR sales milestones in the acute pain market.

MoxDuo CR is expected to launch into the US chronic pain market in 2015.

OxyContin® and MS Contin® are registered trademarks of Purdue Pharma L.P.

About MoxDuo CR
MoxDuo CR is a patented 3:2 ratio fixed dose combination of morphine and oxycodone designed to relieve moderate to severe chronic pain as a once- to twice-a-day formulation. The MoxDuo CR formulation contains proprietary technology to limit tampering or abuse by inhalation or solubilisation in water or alcohol.

About QRxPharma
QRxPharma Limited (ASX: QRX and OTCQX: QRXPY) is a commercial-stage specialty pharmaceutical company focused on the development and commercialisation of new treatments for pain management. Based on a development strategy that focuses on enhancing and expanding the clinical utility of currently marketed compounds, the Company's product portfolio includes both late and early stage clinical drug candidates with the potential for reduced risk, abbreviated development paths, and improved patient outcomes. QRxPharma's lead product candidate, immediate release MoxDuo, has a Prescription Drug User Fee Act (PDUFA) date of 25 June 2012 when the New Drug Application review by the US Food and Drug Administration (FDA) will be completed. The Company recently signed a strategic partnership agreement with Actavis, Inc. to commercialise MoxDuo IR in the US acute pain market, with product launch anticipated in 3Q, CY2012. QRxPharma may co-promote its products in the US and plans to seek strategic partnerships for worldwide markets. Additionally, the Company's clinical pipeline includes an intravenous (IV) and continuous release (CR) formulation of MoxDuo. For more information, visit www.qrxpharma.com.

Forward Looking Statements
This release contains forward-looking statements. Forward-looking statements are statements that are not historical facts; they include statements about our beliefs and expectations. Any statement in this release that states our intentions, beliefs, expectations or predictions (and the assumptions underlying them) is a forward-looking statement. These statements are based on plans, estimates and projections as they are currently available to the management of QRxPharma. Forward-looking statements therefore speak only as of the date they are made, and we undertake no obligation to update publicly any of them in light of new information or future events. By their very nature, forward-looking statements involve risks and uncertainties. A number of important factors could therefore cause actual results to differ materially from those contained in any forward-looking statement. Such factors include risks relating to the stage of products under development; uncertainties relating to clinical trials; dependence on third parties; future capital needs; and risks relating to the commercialisation of the Company's proposed products.

SOURCE QRxPharma


sounds awesome!!!!!!!
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#23 hydropersistant

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Posted May 24 2012 - 08:16 PM

Oh my god porckchop! That sounds like pure fucking heaven! Imagine taking 4 of those thing! 120mgs of M and 80mgs of oxy oh god! That is honest some fucking amazing sounding shit!

#24 codynunn6

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Posted May 26 2012 - 04:47 PM

great find!!

#25 SpENS93

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Posted June 10 2012 - 05:23 PM

heroin

#26 happydude_60

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Posted June 11 2012 - 02:16 AM

Sounds cool. But I can't wait for Zohydro.

#27 Brady_to_Moss

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Posted June 11 2012 - 06:25 AM

The U.S. consumes 99 percent of the world's hydrocodone and 83 percent of its oxycodone, according to a 2008 study by the International Narcotics Control Board, CBS News added.


http://www.huliq.com...w-addiction-med



God this country has issues. 99%...i wonder what % actual uses that for legitament reason...25%? So many dam junkies
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#28 SpENS93

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Posted June 11 2012 - 08:44 AM

DAMN 99% of the worlds hydrocodone??

#29 etkearne

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Posted June 12 2012 - 08:44 AM

DAMN 99% of the worlds hydrocodone??


Most of the developing world just uses Morphine for pain relief. Also, the USA is very liberal in dispensing opioids for outpatient pain care compared to most of the world.
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#30 happydude_60

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Posted June 12 2012 - 12:12 PM

Hydrocodone isn't available in some places, such as the UK, Germany, Belgium, The Netherlands, etc. I'm not sure about Canada. So it doesn't really surprise me that we use such a high percentage of the supply.