Step by step making synthetic cocaine anyone?
Posted September 28 2010 - 06:57 AM
Thank you in advance!
Posted September 28 2010 - 08:52 AM
First the precursors needed are heavily watched by LE but more importantly synthesizing cocaine is supposedly one of the harder syntheses( not quite lsd hard but similar to the difficulty of synthesizing mescaline).
Your best bet as far as cost vs product would be to buy a half to an ounce of decent quality street coke and purify it with a solvent like acetone to get rid of unsoluble cuts.
Posted October 10 2010 - 07:28 PM
Posted December 23 2010 - 08:19 AM
Posted December 25 2010 - 09:23 PM
Posted December 26 2010 - 09:37 PM
FYI I've done coke straight out of a Mecrk bottle right off a plane from Germany in the 80's and it's speeding, jittery, you'll never get it up, and your face will feel like it's shot full of novacaine to the point where you'll drool all over your shirt.
Like weed, it's not just one chemical that gets you high and/or modifies the high in blow.
Posted December 26 2010 - 10:13 PM
Posted December 27 2010 - 08:40 PM
Posted December 27 2010 - 09:22 PM
Merck's cocaine was speedy and jittery probably because it was near 100% pure. It was, however, and still is derived from coca. There are very few, but some, legitimate coca farms.
Not all of it. Some was built from scrath ( I knew a guy who knew a guy.... And all the Merck stuff was 100% (within the margin of Uncertainty-- it melted like a snow flake on a hot plate).
You appear to know a thing or two...
I know all about coke farms and labs, from personal experience. Thier is no aspect of cocaine I have not been involved with.
The quality of the product is largely dictated by the various alkailoid ratios present in the leaf.
Maybe you're more chemist than me?
Here's an interesting hypothesis:
When coke HCL started getting big, it was generally crystalized from di-ethly ether on bed sheets hanging on lines. Less than 3 ki per sheet was typical.
This was "flake". the best stuff.
Later, "rock" or "crystal" was massively produced in containers, from buckets to oil drums, and crystalized from the solvent-of-the-day-- the coke fun thing went to hell.
In the mid 80's. I knew this guy with a Ph.D who worked in columbia. we used to talk, and he told me that the insanity part of coke came with the switch in manufaturing. He said the "bucket method" resulted in a higher % of Tropacocaine, and that Tropacocaine was the problem, not cocaine per se. unfourtunetly, he died and untimely death and never investigated the matter as far as I know. Haven't thought about it in a while.
Got an opinion on that?
Posted January 09 2011 - 10:15 AM
FWIW, laws changed some time ago, lots of coca is produced perfectly legally in south america, and in countries like bolivia it's a right to grow. Out of date info above.
Pure cocaine should not feel overly jittery, and shouldn't have an overly numbing effect, it comes on much slower than typically cut cocaine and a warm numbness build slowly, you come down cleanly and without emptiness. When totally pure it's almost impossible to use, you'll need a 4% cut to get it to stop from clumping in normal air, more humidity means more absorbent cut to make it usable.
Posted January 09 2011 - 10:21 AM
Posted July 03 2013 - 09:28 AM
The first step involves a ring coupling Mannich reaction using methylamine, succindialdehyde, and acetonedicarboxylic acid monomethyl ester in high dilution in a buffered, aqueous solution at 25°C. After 2 days, the reaction mixture is made basic and extracted with chloroform to give racemic 2-carbomethoxytropinone; tropinone is the major impurity. Enantiomeric resolution of the racemate can be accomplished at this point with (+)- and (-)-tartaric acid; however, as noted above, none of the operators of the three clandestine laboratories seized to date attempted such a resolution.
In step two, the 2-carbomethoxytropinone is dissolved in a minimal volume of ice-cold dilute sulfuric acid and reduced to methyl ecgonine with a 1 to 1.5% Na/Hg amalgam at pH 3.5 and 5°C. Reaction conditions are critical; poor pH and/or temperature control results in both decarboxylation of 2-carbomethoxytropinone to tropinone (which is, in turn, reduced to tropine and pseudotropine) and C-2 epimerization of methyl ecgonine to pseudoecgonine methyl ester. After several hours, the reaction is made basic, extracted with chloroform, and evaporated to an oil containing methyl ecgonine and pseudoecgonine methyl ester in an approximate 3:1 ratio. Additional impurities usually include tropinone, tropine, pseudotropine and unreacted 2-carbomethoxytropinone. The majority of pseudoecgonine methyl ester is precipitated from the oil by the addition of diethyl ether and removed via filtration. The filtrate is evaporated to dryness, dissolved in diethyl ether and converted to the hydrochloride. None of the operators of the three clandestine laboratories seized to date attempted to purify their methyl ecgonine any further than the pseudoecgonine methyl ester precipitation step.
In step three, the methyl ecgonine hydrochloride is benzoylated with benzoyl chloride in pyridine near 0°C. After 24 h, the reaction mixture is allowed to warm to room temperature and is diluted with diethyl ether, which precipitates a cocaine HCl/pyridine HCl complex. This precipitate is filtered and washed with additional ether to remove excess pyridine, dissolved in water, and extracted with additional ether to remove benzoic acid. The resulting aqueous solution is made basic with dilute ammonium hydroxide (causing dissociation of the cocaine HCl/pyridine HCl complex), and repeatedly extracted with methylene chloride. The combined extracts, which also contain the remaining free pyridine, are evaporated to dryness to give cocaine base, which is re-dissolved in diethyl ether/acetone 1:1 and converted to the hydrochloride via addition of a stoichiometric amount of concentrated hydrochloric acid. As noted above, the clandestine manufacture of illicit synthetic cocaine is extremely unusual. This is not surprising, because - even when attempted by a skilled chemist - the preparation of (-)-cocaine via total synthesis proceeds in less than 10% overall yield. This is clearly economically infeasible in view of the relatively low cost and ready availability of illicit natural cocaine.