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can anyone shed some light on morphine and chitosan?


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#1 CherokeeMist

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Posted October 25 2009 - 12:46 PM

from what i'm reading, the product chitosan can increase the nasal bioavailability of morphine from 10-15% to just under 60%, which is pretty incredible. here's a link: http://jpet.aspetjou...lickfind.com.au

but i can't find information anywhere on WHAT exactly this formulation is supposed to look like. do you swallow a capsule of chitosan and then snort the morphine? or do you have to combine these things in one big pile of powder and snort them at the same time?

if anyone could answer any of these questions i'd really appreciate it, i can't find much info on this anywhere.
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#2 does2

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Posted October 25 2009 - 05:09 PM

I have asked this on many boards and never heard a conclusive response.

I think this is something somebody would have try and then post about.
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#3 CherokeeMist

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Posted October 26 2009 - 02:32 PM

damn yeah it's such a promising idea, there should be more experimenting with it.

i only have one 30mg morphine tablet in possession and the prospect of getting any more is pretty much non existent, so i don't really have the means to be trying things out. but if i do come into a lot more i'm definitely gonna set a few aside and see what's up.

from what i'm reading it is a little more complicated than just mixing the two and railing them... hmmmmmm...
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keening lovely & awful,
ululate the lost Great American Novels —
An unlawful lot, left to stutter and freeze, floodlit.
(But at least they didn't run,
to their undying credit)

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#4 ILL BILL NECRO

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Posted October 26 2009 - 07:53 PM

cool... never herd of this before... good find
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#5 Feelings 0f U4ia is Back!

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Posted November 05 2009 - 03:54 PM

Nasal Morphine? *shudders*

Rectal or IV. Otherwise just throw it in the toilet.

#6 CherokeeMist

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Posted November 05 2009 - 03:59 PM

well yeah that was my idea... nasal morphine normally is a complete waste but this article is saying that the BA can be increased from 10-15% to over 60% which i think is definitely worth exploring.
While across the great plains,
keening lovely & awful,
ululate the lost Great American Novels —
An unlawful lot, left to stutter and freeze, floodlit.
(But at least they didn't run,
to their undying credit)

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#7 Feelings 0f U4ia is Back!

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Posted November 05 2009 - 04:04 PM

Interesting. I have never heard of this, but I hate morphine, no matter which way I've tried it. IV feels like...dirty...and snorting made me puke my head off my shoulders for 10 hours off the smallest dose ever. Oral didn't do SHIT, and rectal gave me a tiny tiny body buzz, nothing more. But I am interested in knowing more about this...time to do some research.

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#8 CherokeeMist

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Posted November 05 2009 - 04:07 PM

yeah morphine wasn't all that great when i plugged it, as far as pills go they're definitely not my first choice. i can't find ANY information about how exactly to prepare this/how to take each substance and if anything else is involved.

and yes, welcome back :)
While across the great plains,
keening lovely & awful,
ululate the lost Great American Novels —
An unlawful lot, left to stutter and freeze, floodlit.
(But at least they didn't run,
to their undying credit)

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#9 Feelings 0f U4ia is Back!

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Posted November 05 2009 - 04:15 PM

http://forum.opiophi...php/t-7745.html

http://www.ncbi.nlm....pubmed/11907197

http://www.drugs-for...ead.php?t=31423

http://bluelight.ru/...ad.php?t=418662

http://www.bluelight...p/t-420635.html




See if any of those shed some more light.

#10 CherokeeMist

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Posted November 05 2009 - 04:23 PM

hm well this is still the biggest barrier i've come across:

"Well I have found LOTS of info about chitosan and studies of them using it with MS contin but all the studies ever say is they use a Chitosan-MS Contin solution. So i dunno how they are using it :( I am thinking about getting some of this stuff from my local GNC or Health Food Store but should I snort it or take it orally? Also I can't believe out of all the people on this forum who have done MS contin none of them have tried it with chitosan!!! The study I read said it took nasal bio-availability from 10% to 60-75%!!!!!!!!!!!! but once again I do not know how they are administering the Chitosan."


from that first link.

the articles i'm reading are very nonspecific about how exactly this is done. i'd like to find an in depth description of one of these studies with some time frames, "recipes", any other relevant information, etc.
While across the great plains,
keening lovely & awful,
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An unlawful lot, left to stutter and freeze, floodlit.
(But at least they didn't run,
to their undying credit)

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#11 Feelings 0f U4ia is Back!

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Posted November 05 2009 - 04:29 PM

Mix it with the Morphine into a solution and spray it up the nose? My best guess.

#12 StonedAge

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Posted November 05 2009 - 07:23 PM

Mix it with the Morphine into a solution and spray it up the nose? My best guess.

I would bet on it.

Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution
Results. A statistically significant linear dose response was observed over the IN morphine dose range for 4-hour total pain relief. Patients reported statistically significant pain relief and pain intensity differences following IV morphine and IN morphine at doses of 7.5 mg and greater within 30 minutes postdose, compared with placebo. Median times to rescue medication were 124 and 140 minutes for IN morphine 7.5 mg and 15 mg dosage groups, respectively, and 130 minutes for IV morphine. Local adverse events associated with IN morphine were transient and mostly mild (bad taste, nasal congestion, throat irritation, and sneezing). Systemic adverse events, regardless of route of administration, were dose-related and consistent with expected opioid effects.
http://www3.intersci...422257/abstract


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#13 polecat

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Posted April 07 2011 - 02:54 PM

hola hipforums, been a while. I know I'm resurrecting a corpse of a thread, but I was doing some chitosan/ms contin research and up popped the purple forum. Anyhoo, I've both chitosan and morphine and was planning on doing some experimenting this evening. My two strategies are to spray up the chit and then do a line of morph or mix both into a syringe and spray up at the same time. Hoping for good results... I'll report back
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#14 Bluez_Snooze

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Posted April 07 2011 - 03:32 PM

hola hipforums, been a while. I know I'm resurrecting a corpse of a thread, but I was doing some chitosan/ms contin research and up popped the purple forum. Anyhoo, I've both chitosan and morphine and was planning on doing some experimenting this evening. My two strategies are to spray up the chit and then do a line of morph or mix both into a syringe and spray up at the same time. Hoping for good results... I'll report back



yeah please do. i read about this awhile back when i was on morphine. morphine worked like shit for me because of its terrible BA, but i'm wondering if the chitosan will have a worthwhile effect.
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#15 polecat

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Posted April 09 2011 - 08:37 PM

sorry about the slow response.

Anyways, it worked awesome as far as I can tell. Instead of 5 15mg pills each for a decent but light high, my gf and I SPLIT 5 and got high as hell. Basically I put 100mgs of chitosan per 5mL into a syringe. Sprayed 5mL up each nostril (which was nasty), waited a little bit for things to clear out a bit and did a 7.5mg line up each nostril. Kind of an unpleasant method, but seemed worth it.

Also, to be completely I was doing poppy tea as well. It was mediocre but certainly contributed to the high. I've done morphine and poppy together as well but not this particular brand of poppy so that might have contributed to the exceptional high. Did a repeat last night with everything the same and still got a great powerful high. Highly recommend anyone with morphine and an aversion to injection go ahead and try it out because this is the most effective method I've done yet.
PS)All potentiated with tagemet, tonic, and wgfj.
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#16 Pillowpantslol

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Posted April 15 2011 - 06:57 PM

Dissolve it in water and shoot it in your butt, 75%+ BA. Very nice.