how to hydrolize lisdexamfetamine in vyvanse

Discussion in 'Drug Chemistry' started by justsayno0, Aug 12, 2007.

  1. justsayno0

    justsayno0 Member

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    lisdexamfetamine is made up of L-lysine and d-amphetamine. When takin the bodies amino acids break down and hydrolize the L-lysine from the d-amphetamine, slowly releasing the d-amphetamine so it can become active. My question is, is there a way to hydrolize lisdexamfetamine so you can activate the d-amphetamine before taking it? So you can turn the extended release into instant release and have the euphoric effect of adderall.
     
  2. framesh1ft

    framesh1ft Member

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    my best guess for the time being /// charge the amino group with some acid (i don't know the pK right now) run on a CE column and elute with a gradient of methanol ----> methanol + diethanoloamine base solution.
     

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